What does the research say about four-protein score?

Four-protein score

There is 1 paper on four-protein score in aging research: 1 observational study in people. The newest story, Nov 2, 2026: “Four-protein score better predicts death in UK Biobank”.

Biomarker

1 paper studies it2 findings

See all 1 papers on four-protein score

“The derived PS4 score significantly outperformed established non-invasive scores in predicting all-cause mortality across the expanded cohort.”

Proteomic resolution of the MASLD cardiometabolic spectrum identifies sex-driven endotypes and predicts systemic mortalityGut2026doi:10.1136/gutjnl-2026-338674

Humans1

Effects

Mortality

mediatesin humans1

1 study

Four-protein score is linked with mortality in humans (of phenotypic class on mortality outcome) (10-20%).
“The PS4 components, linked to hepatic lipid/one-carbon metabolism (FABP1, FTCD) and immune/vascular integrity (ADGRG1, GAST) pathways, were found to account for a significant fraction (10-20%) of the estimated effect”
Humansof phenotypic class on mortality outcome
Four-protein score better predicts death in UK Biobank
GutJul 29, 2026

Associations

Mortality

upin humans1

1 study

Four-protein score predicts mortality in cohort with/without MRI-PDFF data.
“The derived PS4 score significantly outperformed established non-invasive scores in predicting all-cause mortality across the expanded cohort.”
Humansin cohort with/without MRI-PDFF data>15-yearn = 115,971
Four-protein score better predicts death in UK Biobank
GutJul 29, 2026

Latest

1 paper in 12 months

GutJul 30

Four-protein score better predicts death in UK Biobank

Researchers validated a four-protein score in an observational cohort of 115,971 people, comparing its predictions with established noninvasive scores.Researchers validated a four-protein score in an observational cohort of 115,971 people, comparing its predictions with established noninvasive scores.

Cohort · 115,971 peopleBiomarkers

Paper