Fasting proinsulin

Fasting proinsulin predicts glucose tolerance deterioration in humans (AUC 0.710; cutoff 5.1 pmol/L: 68.8% sensitivity, 83.8% specificity).

HumansExploratory ROC analysis in community-dwelling Japanese adultsserum4 yearsn = 84

Fasting proinsulin as a predictor of future glucose tolerance deterioration in Japanese adults

Journal of diabetes investigation·7 Oct 2026

Fasting proinsulin is associated with glucose tolerance deterioration in humans (OR 2.11 per 1-SD increase, 95% CI 1.31–3.72).

HumansCommunity-dwelling Japanese adults; per 1-standard deviation increase in fasting proinsulinserum4 yearsn = 84

Fasting proinsulin as a predictor of future glucose tolerance deterioration in Japanese adults

Journal of diabetes investigation·7 Oct 2026