Endogenous siRNAs
1 paper1 finding
- Model organisms1
Effects
1Lifespan extension
is required forin worms1
1 study
Lifespan extension
is required forin worms1
Endogenous siRNAs is required for lifespan extension in worms.
“altered levels of endogenous siRNAs, which are required for the longevity and healthspan benefits of INTS-11 depletion.”
Model organismsrequired for the longevity benefits of INTS-11 depletion
Adulthood depletion of Integrator extends lifespan and healthspan via defective pre-mRNA processing
bioRxiv : the preprint server for biologyApr 21, 2026Preprint
Funding
1 grant since 2019Israel Science Foundation₪270k
Latest
1 in 12 monthsbioRxiv
Adulthood depletion of Integrator extends lifespan and healthspan via defective pre-mRNA processing
Preprint: experiments in wormsMechanisms
eLife
Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans
Experiments in model organismsMechanisms