What does the research say about disease age gap?

Disease age gap

There is 1 paper on disease age gap in aging research: 1 observational study in people. The newest story, Nov 14, 2026: “Blood protein scores linked to future age-related disease”.

Biomarker

1 paper studies it5 findings

1 new paper in 30 daysSee all 1 papers on disease age gap

“The resulting disease age gap separated 10-year incidence up to 20-fold among individuals of the same chronological age”

Disease aging clocks in the plasma proteome stratify risk and track preclinical progressionResearch Square2026doi:10.21203/rs.3.rs-10675323/v1

Humans1

Associations

Proximity to disease diagnosis

upin humans1

1 study

Disease age gap is associated with proximity to disease diagnosis in humans (Participants who subsequently developed disease) (19 of 20 diseases).
“Among participants who went on to develop disease, the gap was larger closer to diagnosis in 19 of 20 diseases”
HumansParticipants who subsequently developed disease
Blood protein scores linked to future age-related disease
Research SquareNov 13, 2026Preprint

Alzheimer's disease

upin humans1+17% higher hazard per additional year of gap

1 study

Disease age gap is associated with Alzheimer's disease in humans (17% higher hazard per additional year of gap).
“each additional year of gap raised the hazard of type 2 diabetes by 24%, chronic kidney disease by 21% and Alzheimer′s disease (AD) by 17%.”
HumansEach additional year of disease age gapn = 44,526
Blood protein scores linked to future age-related disease
Research SquareNov 13, 2026Preprint

Latest

1 paper in 12 months

Research SquareNov 14

Blood protein scores linked to future age-related disease

In 44,526 UK Biobank participants, 10-year disease incidence differed up to 20-fold between people of the same age with different scores.In 44,526 UK Biobank participants, 10-year disease incidence differed up to 20-fold between people of the same age with different scores.

Preprint: cohort · 44,526 peopleBiomarkers

Paper

Disease age gap

Associations

Latest

Blood protein scores linked to future age-related disease

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