Default mode network connectivity
1 paper4 findings
In a human study, default mode network connectivity is associated with verbal fluency and with abdominal obesity and low HDL cholesterol as midlife metabolic syndrome components; midlife metabolic syndrome decreases connectivity.
Findings from 1 paper from September 2026
- Humans1
Upstream
1Metabolic syndrome
downin humans1
1 study
Metabolic syndrome
downin humans1
Metabolic syndrome decreases default mode network connectivity in humans (partial η2 = 0.035, adjusted p = 0.038).
“MetS participants showed reduced within-network connectivity in the default mode network (DMN; adjusted p = 0.038, partial η 2 = 0.035).”
Humansmidlife metabolic syndromebrainn = 223
Frontiers in aging neuroscience9 Sep 2026
Associations
3Verbal fluency
downin humans1
1 study
Verbal fluency
downin humans1
Default mode network connectivity is associated with verbal fluency in humans (partial R2 = 0.037, adjusted p = 0.026).
“Reduced DMN connectivity was associated with poorer verbal fluency (adjusted p = 0.026, partial R 2 = 0.037).”
Humansbrainn = 223
Frontiers in aging neuroscience9 Sep 2026
Low HDL cholesterol
downin humans1
1 study
Low HDL cholesterol
downin humans1
Low HDL cholesterol is associated with default mode network connectivity in humans (partial η2 = 0.058, adjusted p = 0.002).
“cholesterol: adjusted p = 0.002, partial η 2 = 0.058”
Humansmidlife metabolic syndrome componentbrainn = 223
Frontiers in aging neuroscience9 Sep 2026
Abdominal obesity
downin humans1
1 study
Abdominal obesity
downin humans1
Abdominal obesity is associated with default mode network connectivity in humans (partial η2 = 0.029, adjusted p = 0.027).
“abdominal obesity and low HDL cholesterol were associated with reduced connectivity in DMN (abdominal obesity: adjusted p = 0.027, partial η 2 = 0.029; cholesterol: adjusted p = 0.002, partial η 2 = 0.058).”
Humansmidlife metabolic syndrome componentbrainn = 223
Frontiers in aging neuroscience9 Sep 2026