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Conserved age-associated methylation hub across tissues

There is 1 paper on conserved age-associated methylation hub across tissues in aging research: none in people yet. The newest story, Oct 31, 2026: “Human tissues share some age-linked patterns in DNA tags”.

Biomarker

1 paper studies it1 finding

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“A gene encoding a cell-adhesion protein, PCDHGA1, emerged as a conserved hub across tissues”
Meta-analysis of DNA methylation aging signatures in 17 human tissuesNature aging2026doi:10.1038/s43587-026-01164-5
  • In silico1

Associations

1

PCDHGA1

mixedin humans1

1 study

  1. PCDHGA1 is associated with conserved age-associated methylation hub across tissues in humans.

    “A gene encoding a cell-adhesion protein, PCDHGA1, emerged as a conserved hub across tissues”

    Humansmultiple tissuesn = 15,000

    Human tissues share some age-linked patterns in DNA tags

    Nature aging

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Nature Aging

Human tissues share some age-linked patterns in DNA tags

A computational meta-analysis of more than 15,000 human methylation profiles across 17 tissues found both common and tissue-specific associations with age.A computational meta-analysis of more than 15,000 human methylation profiles across 17 tissues found both common and tissue-specific associations with age.

Meta-analysisMechanisms
Paper

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