Brain ProtBAG

Brain ProtBAG predicts chronological age in humans (r = 0.63, MAE = 4.55).

“In addition, the brain and hepatic showed the highest Pearson's r values (Linear SVR: 0.62 and 0.64 for the brain and hepatic ProtBAGs; LASSO 0.63 and 0.65 for the brain and hepatic ProtBAGs)”

HumansLASSO modelcsfn = 736

ProtBAG: Eleven organ‐specific proteome‐based biological age using CSF proteomics · AAIC 2025 abstract · 24 Dec 2025

Brain ProtBAG predicts chronological age in silico (MAE 4.55, r = 0.63).

“The brain and hepatic showed the lowest MAE values (Linear SVR: 4.56 and 4.52 for the brain and hepatic ProtBAGs; LASSO 4.55 and 4.52 for the brain and hepatic ProtBAGs)”

In silicoLASSO model in CSF proteomicsn = 736

ProtBAG: eleven organ‐specific proteome‐based biological age using CSF proteomics · AAIC 2025 abstract · 23 Dec 2025