Brain free water
1 paper5 findings
A human study associates higher brain free water with higher systolic blood pressure and smaller hippocampal, white matter and grey matter volumes. It also reports that brain free water mediates the relationship between systolic blood pressure and Montreal Cognitive Assessment scores.
- Humans1
Effects
1Montreal Cognitive Assessment
mediatesin humans1
1 study
Montreal Cognitive Assessment
mediatesin humans1
Brain free water mediates Montreal Cognitive Assessment in humans (accounting for 45.04% of the total effect).
Humansrelationship between SBP and MoCA scoren = 984
European journal of radiology29 Jul 2026
Associations
4Hippocampal volume
downin humans1
1 study
Hippocampal volume
downin humans1
Brain free water is associated with hippocampal volume in humans (β = -0.449, 95% CI, -0.650 to -0.038).
Humansn = 984
European journal of radiology29 Jul 2026
White matter volume
downin humans1
1 study
White matter volume
downin humans1
Brain free water is associated with white matter volume in humans (β = -1.373; 95% CI, -1.621 to -1.126).
Humansn = 984
European journal of radiology29 Jul 2026
Gray matter volume
downin humans1
1 study
Gray matter volume
downin humans1
Brain free water is associated with gray matter volume in humans (β = -0.558; 95% CI, -0.766 to -0.349).
Humansn = 984
European journal of radiology29 Jul 2026
Systolic blood pressure
upin humans1
1 study
Systolic blood pressure
upin humans1
Systolic blood pressure is associated with brain free water in humans (r = 0.30, P < 0.001).
Humansn = 984
European journal of radiology29 Jul 2026