Biologic PREVENT variants

Biomarker

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  • Humans1

Effects

1

Mortality prediction discrimination

downin humans1

1 study
  1. Biologic PREVENT variants decrease mortality prediction discrimination in humans (ΔC −0.011 to −0.081; chronologic PREVENT all-cause mortality C=0.744).

    “Chronologic PREVENT demonstrated superior discrimination (C=0.744 for all-cause mortality) compared with epigenetic substitutions (ΔC −0.011 to −0.081).”

    Humanscompared with chronologic PREVENTepigenetic age substitutions in PREVENT equations17.4 yearsn = 1,516

    Replacing calendar age did not improve a heart risk model

    ESC Congress 2026 abstract

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ESC Congress 2026 Abstract

Replacing calendar age did not improve a heart risk model

For deaths from any cause, prediction scores were 0.744 using calendar age and 0.011–0.081 lower after researchers substituted DNA-based age.For deaths from any cause, prediction scores were 0.744 using calendar age and 0.011–0.081 lower after researchers substituted DNA-based age.

Cohort · 1,516 peopleBiomarkers