Aneuploidy frequency

1. ERCC1 has no effect on aneuploidy frequency in mice.

   “Bub1b(H/H), but not Ercc1(-/Δ7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-type controls in the cerebral cortex”

   AnimalsErcc1(-/Δ7) mutationcerebral cortex

   Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice

   Human molecular genetics·17 Dec 2015

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1. BUB1B increases aneuploidy frequency in mice (reaching a frequency as high as 40.3%).

   “Bub1b(H/H), but not Ercc1(-/Δ7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-type controls in the cerebral cortex”

   AnimalsBub1b(H/H) mutationcerebral cortex

   Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice

   Human molecular genetics·17 Dec 2015

More on BUB1B