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AI-ECG-estimated maximal oxygen uptake

There is 1 paper on AI-ECG-estimated maximal oxygen uptake in aging research: 1 observational study in people. The newest story, Nov 7, 2026: “AI fitness estimates from heart recordings linked to death risk”.

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“the highest quartile was associated with 54% lower risk of all-cause mortality (HR 0.46 95%CI 0.40-0.53; p<0.001)”
Predicting Maximal Oxygen Uptake from a Resting 12-Lead Electrocardiogram Using an Artificial Intelligence-Enabled Algorithm and Its Association with MortalityAHA Scientific Sessions 2026 abstract2026doi:10.1161/circ.154.suppl_1.18023
  • Humans1

Associations

2

Mortality

downin humans1HR 0.46

1 study

  1. AI-ECG-estimated maximal oxygen uptake is associated with mortality in humans (54% lower risk; HR 0.46 (95% CI 0.40–0.53), highest versus lowest quartile).

    “the highest quartile was associated with 54% lower risk of all-cause mortality (HR 0.46 95%CI 0.40-0.53; p<0.001)”

    HumansHighest versus lowest AI-ECG-estimated maximal oxygen uptake quartile, independent of cardiovascular disease and measured maximal oxygen uptakeMedian follow-up of 7.2 years61.5% malessn = 5,398

    AI fitness estimates from heart recordings linked to death risk

    AHA Scientific Sessions 2026 abstract

Measured maximal oxygen uptake

upin silico1

1 study

  1. AI-ECG-estimated maximal oxygen uptake is associated with measured maximal oxygen uptake in silico (Pearson R 0.71; r2=0.49; MAE 4.87 mL/kg/min (95% CI 4.76–4.98)).

    “The AI-ECG model predicted VO 2max with a Pearson R 0.71 (r 2 =0.49) and MAE of 4.87 mL/kg/min”

    In silicoTesting cohort of patients undergoing clinically indicated cardiopulmonary exercise testing61.5% malessn = 5,398

    AI fitness estimates from heart recordings linked to death risk

    AHA Scientific Sessions 2026 abstract

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AHA Scientific Sessions 2026 Abstract

AI fitness estimates from heart recordings linked to death risk

In 5,398 patients, estimates were off by an average of 4.87 milliliters of oxygen per kilogram per minute compared with exercise-test measurements.In 5,398 patients, estimates were off by an average of 4.87 milliliters of oxygen per kilogram per minute compared with exercise-test measurements.

Cohort · 5,398 peopleBiomarkers
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