269-variant multiethnic genetic risk score

269-variant multiethnic genetic risk score is linked with higher prostate cancer prediction discrimination in humans (White men; added to an age-based risk model) (AUC increased by 8.69–11.23%).

“Adding the 269-variant multiethnic score to age in an integrated risk model improved discrimination in White men across all prediction horizons, increasing AUC by 8.69–11.23%.”

HumansWhite men; added to an age-based risk model2, 5, and 10 yearsmales

Prostate cancer gene scores add little beyond age in Black men

Research Square·Nov 11, 2026Preprint