Phase 3Not yet recruiting
Submucosal Cryotherapy and Anti-inflammatory Drugs for Postoperative Pain Following Root Canal Treatment in Maxillary Molars
Effect of Submucosal Cryotherapy With or Without Different Anti-inflammatory Drugs on Postoperative Pain and Interleukin-6 Levels in Maxillary Molars With Symptomatic Irreversible Pulpitis: A Randomized Clinical Study
- Sponsor
- Suez Canal University (Academic or other)
- Enrollment
- 90 planned
- Conditions
- Pulpitis
- Interventions
- Articaine Hydrochloride With Epinephrine; Submucosal Cryotherapy; Diclofenac Sodium; Dexamethasone Sodium Phosphate
- Ages
- adults
- Registry
- NCT07919938
Full record on ClinicalTrials.gov
From the registry
Pain after root canal treatment is a common problem, particularly in teeth with symptomatic irreversible pulpitis, a condition involving severe inflammation of the tissue inside the tooth. Submucosal cryotherapy, which involves applying cold saline through an injection near the affected tooth, may help reduce postoperative pain and inflammation. Anti-inflammatory medications, such as diclofenac sodium and dexamethasone, may also provide pain relief. This randomized clinical trial aims to evaluate the effects of submucosal cryotherapy, alone or combined with anti-inflammatory medications, on postoperative pain and interleukin-6 (IL-6) levels in patients undergoing root canal treatment of upper molars with symptomatic irreversible pulpitis. A total of 90 adult patients will be randomly assigned to six groups: local anesthesia alone, cryotherapy with anesthesia, diclofenac sodium with anesthesia, dexamethasone with anesthesia, cryotherapy combined with diclofenac sodium, or cryotherapy combined with dexamethasone. All participants will undergo standardized single-visit root canal…
Primary outcomes
- Postoperative Pain Intensity Assessed Using the Numeric Rating Scale (NRS)
History
Primary completion expected
Expected to start
Registered