No phaseRecruiting
Effects of Pre-Run Nutritional Supplements During a Fixed-Pace 5 km Treadmill Run
Fueling the Kilometers: Effects of Pre-Run Nutritional Supplements on Physiological Responses During a Fixed-Pace 5 km Treadmill Run
- Sponsor
- St. Louis University (Academic or other)
- Enrolment
- 20 planned
- Conditions
- Exercise Physiology; Nutritional Supplementation
- Interventions
- Caffeine; L-Citrulline; Exogenous Ketone (Beta-Hydroxybutyrate); placebo beverage
- Ages
- adults
- Registry
- NCT07854223
Full record on ClinicalTrials.gov
From the registry
This study will examine how three commonly used pre-run nutritional supplements-caffeine, L-citrulline, and an exogenous ketone supplement-affect physiological and perceptual responses during a fixed-pace 5 km treadmill run in healthy, physically active runners. Participants will complete one screening and baseline visit followed by four experimental visits in a randomized order. At each experimental visit, participants will receive caffeine, L-citrulline, an exogenous ketone supplement, or placebo before completing a fixed-pace 5 km treadmill run. Each participant will receive all four conditions and will therefore serve as their own control. The study will evaluate measures including running economy, heart-rate responses, oxygen consumption, respiratory measures, blood lactate and ketone concentrations, perceived exertion, gastrointestinal symptoms, fatigue, energy, and focus. A randomly selected subgroup will also wear a continuous glucose monitor to explore glucose responses during the experimental visits. The study will also assess the feasibility and tolerability of…
Primary outcomes
- Running Economy (VO₂) During the Fixed-Pace 5 km Treadmill Run
- Heart-Rate Drift During the Fixed-Pace 5 km Treadmill Run
History
Study completion expected
Primary completion expected
Expected to start
Registered