No phaseRecruiting
Chorioretinal Imaging, Vascular Biomarkers, and Ultra-Trail: A Pilot Study (UTMA-RETINA)
- Sponsor
- Centre Hospitalier Universitaire Dijon (Academic or other)
- Enrolment
- 40 planned
- Conditions
- OCT Angiography; Retinal Microcirculation; Choroidal Microcirculation; Physical Exercion
- Interventions
- Retinal imaging evaluation of both eyes without dilation before and after the Mont Afrique Ultra Trail; Retinal imaging evaluation of both eyes without dilation, performed in two stages (T0 and T0+11/24H)
- Ages
- adults, older adults
- Registry
- NCT07748936
Full record on ClinicalTrials.gov
From the registry
Retinal and choroidal microcirculation is a relevant biomarker of systemic vascular health and lies at the heart of eye-heart interactions. Noninvasive retinal imaging, particularly OCT angiography (OCT-A), now makes it possible to examine retinal and choroidal microvascularization in vivo and to study its relationship with systemic cardiovascular and neurovascular mechanisms. Ultra-endurance activities, such as ultra-trail races, induce significant systemic hemodynamic changes, including dehydration, variations in perfusion pressure, prolonged sympathetic activation, and redistribution of blood flow. These physiological adaptations could lead to acute and reversible changes in retinal and choroidal vascular parameters as measured by retinophotography and OCT angiography. Several studies suggest that intense physical exercise may be accompanied by significant changes in retinal and choroidal microvascular perfusion. In particular, a significant decrease in the vascular density of the superficial retinal plexus has been observed following intense exercise in a healthy population,…
Primary outcomes
- Difference in macular vascular density of the superficial capillary plexus between the pre-race and immediate post-race examinations
History
Primary completion expected
Last registry update
Started
Registered