No phaseCompletedHealthspan endpoint
Effects of Peanut Consumption on Brain Function
Longer-term Effects of Peanut Consumption on Brain Function in Older Men and Women
- Sponsor
- Maastricht University Medical Center (Academic or other)
- Enrolment
- 31 enrolled
- Conditions
- Brain Vascular Function; Cerebral Blood Flow; Brain Insulin Sensitivity; Cognitive Performance
- Interventions
- Skin roasted peanuts
- Ages
- adults, older adults
- Registry
- NCT05724654
Full record on ClinicalTrials.gov
From the registry
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is also associated with cognitive decline. Peanut consumption has already been shown to beneficially affect cognitive performance. However, underlying mechanisms have not yet been established, while well-controlled trials on longer-term effects of peanuts on cognitive performance are highly needed. The hypothesis is that longer-term peanut consumption has beneficial effects on (regional) cerebral blood flow responses (primary outcome), which may relate to an improved cognitive performance (secondary outcome) in older men and women. Important objectives are to investigate in older adults the effect of 16-week peanut consumption on (i) brain vascular function in cognitive-control brain areas, and (ii) brain insulin-sensitivity. We will also focus on changes in cognitive performance as assessed with a neuropsychological test battery (secondary objective). Cerebral blood flow responses before (brain vascular function) and after the administration of intranasal…
Primary outcomes
- Brain Vascular Function
- Brain Insulin Sensitivity
History
Last registry update
Primary completion
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