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The POMELO (Prevention Of MusclE Loss in Osteoarthritis) Trial

Targeted Knee Osteoarthritis Care for Adults With a BMI ≥35 kg/m2: the Prevention Of MusclE Loss in Osteoarthritis (P.O.M.E.L.O.) Feasibility and Pilot Randomized Trial

Sponsor
University of Alberta (Academic or other)
Enrollment
50 enrolled
Conditions
Osteoarthritis, Knee; Obesity
Interventions
Intervention
Ages
adults, older adults
Registry
NCT05026385

Full record on ClinicalTrials.gov

From the registry

Treatment options for individuals who have advanced knee osteoarthritis (OA) and a body mass index (BMI) ≥35 kg/m2 are limited, and this patient population may be neglected in current clinical care pathways for OA management. These individuals are considered to be at high risk for complications with total knee arthroplasty (TKA), and as a result may not be eligible for this procedure unless they lose significant weight. However, there is limited evidence for endorsing weight loss as beneficial prior to TKA. Further, unsupervised weight loss could put patients at risk for muscle loss and development of sarcopenic obesity, a health condition that negatively impacts mobility and mortality. This suggests that weight loss might not be the primary treatment goal for this patient population. Integrated non-surgical treatment approaches are needed that can target the specific needs of this knee OA patient group. This study will examine the feasibility and acceptability of a personalized, multicomponent intervention, and its effects on body composition and physical function compared to usual…

Primary outcomes

  • Per-protocol adherence (feasibility)
  • Adverse events
  • Study completion rates (feasibility)
  • Acceptability of Intervention Measure (AIM) score

History

  1. Last registry update

  2. Primary completion

  3. Started

  4. Registered

Papers citing this trial