Phase 2Completed
Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors
Steroid, Thiamine and Ascorbic Acid During Post-Resuscitation Period for Comatose Out-of-hospital Cardiac Arrest Survivors (STAR) Trial: Multi-center, Randomized, Single-blinded, Controlled Pilot Study
- Sponsor
- Asan Medical Center (Academic or other)
- Enrollment
- 160 enrolled
- Conditions
- Out-Of-Hospital Cardiac Arrest; Postcardiac Arrest Syndrome
- Interventions
- The combined supplement of Ascorbic acid, Thiamine, and Cortisol; Placebo
- Ages
- adults, older adults
- Registry
- NCT04921189
Full record on ClinicalTrials.gov
From the registry
The mortality and neurological outcomes among out-of-hospital cardiac arrest survivors have not improved despite the medical advances. The whole body ischemia/reperfusion injuries after cardiac arrest mainly damaged the brain. To improve the neurologic outcome among those patients, additional interventions would be warranted. The investigators hypothesize that the combined use of cortisol, ascorbic acid (vitamin C), and thiamine during the early post-resuscitation period would attenuate the whole-body ischemia/reperfusion injuries among the out-of-hospital cardiac arrest survivors treated with targeted temperature management.
Primary outcomes
- the peak neuron-specific enolase level
History
Last registry update
Study completion
Primary completion
Started
Registered