No phaseCompletedHealthspan endpoint
30-to-90 Day Challenge: Effects of Alcohol Cessation on Health Outcomes
Effects of Experimentally-induced Reductions in Alcohol Consumption on Brain Cognitive and Clinical Outcomes, and Motivation for Changing Drinking in Older Persons With HIV Infection
- Sponsor
- University of Florida (Academic or other)
- Enrollment
- 57 enrolled
- Conditions
- Alcohol Drinking; Chronic Inflammation; Neurocognitive Dysfunction; Liver Diseases; HIV Infections
- Interventions
- Contingency Management (CM)
- Ages
- adults, older adults
- Registry
- NCT03353701
Full record on ClinicalTrials.gov
From the registry
The objective for this project is to determine whether how certain behavioral and health functions change in persons with heavy drinking when they stop (or reduce) drinking for 30 days, and whether changes continue for up to 90 days. The study will also identify barriers and facilitators related to drinking reduction. The project will focus on clinical comorbidities including HIV disease control, cognitive and brain function, liver abnormalities, and chronic inflammation. The study teams propose to enroll 140 HIV+ and 40 HIV- adults with heavy drinking, and then use Contingency Management (CM) with financial incentives to encourage participants to maximally reduce alcohol consumption for 30 days. Participants will be required to wear an ankle biosensor (SCRAM monitor) at all times, which is used to monitor participants' drinking behavior. At 30 days, participants will complete a full day of follow-up, including cognitive testing, neuroimaging, blood testing, liver Fibroscan, and questionnaires. Many participants will also provide a stool sample for gut microbiome assessment at each…
Primary outcomes
- Change in Neurocognitive Functions
History
Last registry update
Study completion
Primary completion
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