Phase 4CompletedHealthspan endpoint
Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial (EFFORT)
- Sponsor
- University Hospital, Basel, Switzerland (Academic or other)
- Enrollment
- 2,088 enrolled
- Conditions
- Malnutrition
- Interventions
- Nutritional therapy
- Ages
- children, adults, older adults
- Registry
- NCT02517476
Full record on ClinicalTrials.gov
From the registry
The aims of the randomized-controlled, multicenter EFFORT trial are to assess the effects of early nutritional therapy in regard to effectiveness, safety and costs when applied to the heterogenous, polymorbid medical inpatient population. EFFORT will not only answer the question about overall benefit or harm, but using a physio-pathological mechanistic approach, it also will explore and provide conclusive answers about whether, why, how, and in which patient populations nutritional therapy does and does not works.
Primary outcomes
- primary composite endpoint
History
Last registry update
Study completion
Primary completion
Registered
Started
Papers citing this trial
- Trimethylamine N-oxide (TMAO) as a prognostic marker among patients at nutritional risk. A secondary analysis of the randomized clinical trial EFFORT
European journal of clinical nutrition
- Comparison of the inflammatory biomarkers IL- 6, TNF-α, and CRP to predict the effect of nutritional therapy on mortality in medical patients at risk of malnutrition : A secondary analysis of the randomized clinical trial EFFORT
Journal of inflammation (London, England)
- Evaluating repeated handgrip strength measurements as predictors of mortality in malnourished hospitalized patients. Secondary analysis of a randomized controlled trial
European journal of clinical nutrition
- Urea-to-creatinine ratio as a biomarker for clinical outcome and response to nutritional support in non-critically ill patients: A secondary analysis of a randomized controlled trial
Clinical nutrition ESPEN
- Low plasma pancreatic lipase as a novel predictor of nutritional target achievement and response to nutritional interventions in malnourished inpatients: Secondary analysis of a randomized clinical trial
Clinical nutrition (Edinburgh, Scotland)
- Association of phenylalanine and tyrosine metabolism with mortality and response to nutritional support among patients at nutritional risk: a secondary analysis of the randomized clinical trial EFFORT
Frontiers in nutrition
- Sex differences in clinical presentation, treatment response, and side effects of nutritional therapy among patients at nutritional risk: a secondary analysis of the randomized clinical trial EFFORT
The American journal of clinical nutrition
- Association of leucine and other branched chain amino acids with clinical outcomes in malnourished inpatients: a secondary analysis of the randomized clinical trial EFFORT
European journal of clinical nutrition