Advanced Science
Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice
The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic…The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic deficits.
Experiments in miceHuntington's disease