Papers by X. Chen

351 results

  1. Nature Neuroscience

    Genetic data highlight potential drug targets for Alzheimer's

    A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.

    Mendelian randomisation in 111,680 peopleAlzheimer's disease
  2. Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies

    Wearable patch matched artery signals with high accuracy

    In experiments with 110 participants, the patch achieved 96.14% waveform similarity to medical-grade equipment without needing calibration for each person.In experiments with 110 participants, the patch achieved 96.14% waveform similarity to medical-grade equipment without needing calibration for each person.

    Trial in 110 peopleInterventions
  3. Alzheimer's & Dementia

    Brain receptor gene activity linked to lower Alzheimer’s risk

    An analysis of inherited genetic differences linked a hormone receptor’s gene activity to lower disease risk, with results pointing mainly to the brain’s outer layer.An analysis of inherited genetic differences linked a hormone receptor’s gene activity to lower disease risk, with results pointing mainly to the brain’s outer layer.

    Mendelian randomisation in peopleMechanisms
  4. Nature Communications

    Targeting a cell regulator reduced bone loss in mice

    In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.

    Experiments in miceBones and joints