Papers by Meng Zhang

17 results

  1. Free Radical Biology & Medicine

    Two PDE4 inhibitors extend lifespan in worms

    In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated…In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated oxidative stress.

    Experiments in wormsInterventions
  2. bioRxiv

    T cell KRAS upregulation is linked to premature coronary disease

    Profiling blood and plaque samples from 12 patients and 21 controls linked elevated KRAS in senescent CD8+ T cells to premature coronary artery disease.Profiling blood and plaque samples from 12 patients and 21 controls linked elevated KRAS in senescent CD8+ T cells to premature coronary artery disease.

    Preprint: case-control study in peopleKRAS