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Papers by Chang Chen

15 results

  1. HGG Advances

    Summary-level genetic method improves Alzheimer's risk prediction

    The endoPRS-SS framework boosted computational efficiency up to 90-fold while using summary statistics and multiple endophenotypes to improve Alzheimer's disease risk…The endoPRS-SS framework boosted computational efficiency up to 90-fold while using summary statistics and multiple endophenotypes to improve Alzheimer's disease risk prediction.

    Computational studyAlzheimer's disease
    Paper
  2. Frontiers in Aging Neuroscience

    COVID-19 tied to higher dementia risk in older adults with diabetes

    Older adults had an overall dementia hazard ratio of 1.51 after documented infection compared with matched uninfected peers across up to six years of follow-up.Older adults had an overall dementia hazard ratio of 1.51 after documented infection compared with matched uninfected peers across up to six years of follow-up.

    Cohort study of 449,745 peopleVascular dementia
    Paper