TIE2 gene therapy

Intervention1 paper1 finding

  • Animals1

Outcomes

1

Schlemm's canal niche age-related changes

downin mice1Very low certainty

1 study

  1. TIE2 gene therapy protects against schlemm's canal niche age-related changes in mice.

    Animalsduring aging

    Macrophage-derived VEGFA maintains eye outflow in mice · bioRxiv : the preprint server for biology · 11 Sep 2026 · Preprint

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bioRxivAnimalsPreprint

Macrophage-derived VEGFA maintains eye outflow in mice

Deleting Vegfa in CX3CR1-positive macrophages raised intraocular pressure and reduced aqueous humor outflow facility in nine-month-old mice.Deleting Vegfa in CX3CR1-positive macrophages raised intraocular pressure and reduced aqueous humor outflow facility in nine-month-old mice.

Eye

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