1 paper4 findings
Bone architecture deterioration
upin mice1
Hyodeoxycholic acid improves bone architecture deterioration in mice.
“In OVX mice, oral HDCA administration replenished systemic HDCA levels, reversed bone architecture deterioration, and activated TGR5-ESR1 signaling in both intestinal and bone tissues.”
Animalsin OVX micebone
Bile acid corrected abnormal fat-cell formation in human cells
Journal of advanced research10 Oct 2026
Mitophagy
upin human cells1
Hyodeoxycholic acid activates mitophagy in human cells.
“triggers PINK1/Parkin-mediated mitophagy to restore mitochondrial quality control.”
Cellsin patient-derived BMSCs
Bile acid corrected abnormal fat-cell formation in human cells
Journal of advanced research10 Oct 2026
Adipogenesis
downin human cells1
Hyodeoxycholic acid inhibits adipogenesis in human cells.
“Exogenous HDCA treatment dose-dependently inhibited senescence and corrected aberrant adipogenesis in patient-derived BMSCs.”
Cellsin patient-derived BMSCs
Bile acid corrected abnormal fat-cell formation in human cells
Journal of advanced research10 Oct 2026
Cellular senescence
downin human cells1
Hyodeoxycholic acid inhibits cellular senescence in human cells.
“Exogenous HDCA treatment dose-dependently inhibited senescence and corrected aberrant adipogenesis in patient-derived BMSCs.”
Cellsin patient-derived BMSCs
Bile acid corrected abnormal fat-cell formation in human cells
Journal of advanced research10 Oct 2026
Lab experiments in bone marrow cells from patients with postmenopausal osteoporosis also found reduced senescence, a state in which cells stop dividing.Lab experiments in bone marrow cells from patients with postmenopausal osteoporosis also found reduced senescence, a state in which cells stop dividing.