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Fluzone high-dose

Fluzone high-dose has been studied in 1 paper since 2025: 1 trial in people. The newest paper, Oct 30, 2025: “Comparative analysis of cellular immune responses to four seasonal inactivated influenza vaccines in younger and older adults”.

Intervention

1 paper studies it3 findingsUpdated

See all 1

“FHD, which contains 4 times more antigen content than the other vaccines, elicited superior cellular responses compared to FAD in older participants.”
Comparative analysis of cellular immune responses to four seasonal inactivated influenza vaccines in younger and older adultsJournal of immunology (Baltimore, Md. : 1950)2025doi:10.1093/jimmun/vkaf286

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Centers for Disease Control and Prevention and others
  • Human trial1

Studies in people

1 study gave fluzone high-dose to people and measured what changed.

What did studies of Fluzone high-dose find?

3

Studies of Fluzone high-dose measured 3 outcomes; the most studied are immune response (1 study), antibody-secreting cells (1) and immune response (1).

Immune response

upin humans1

1 study

  1. Fluzone high-dose improves immune response in elderly participants, compared to FAD.

    “In elderly participants, the FHD vaccine induced a greater magnitude of H1 AIM+ T cells (D7) than those vaccinated with FAD (P = 0.01).”

    Human trialin elderly participants, compared to FAD90 d

    Comparative analysis of cellular immune responses to four seasonal inactivated influenza vaccines in younger and older adults

    Journal of immunology (Baltimore, Md. : 1950)

Antibody-secreting cells

upin humans1

1 study

  1. Fluzone high-dose increases antibody-secreting cells in humans (compared to FAD).

    “Simultaneously, there was an increase in ASCs in participants vaccinated with FHD (P = 0.04) 7 d after vaccination, which had a higher peak in ASCs compared to FAD-vaccinated participants (P = 0.02).”

    Human trialcompared to FAD90 d

    Comparative analysis of cellular immune responses to four seasonal inactivated influenza vaccines in younger and older adults

    Journal of immunology (Baltimore, Md. : 1950)

More on Antibody-secreting cells

Immune response

upin humans1

1 study

  1. Fluzone high-dose improves immune response in humans.

    “FHD, which contains 4 times more antigen content than the other vaccines, elicited superior cellular responses compared to FAD in older participants.”

    Human trial

    Comparative analysis of cellular immune responses to four seasonal inactivated influenza vaccines in younger and older adults

    Journal of immunology (Baltimore, Md. : 1950)

More on Immune response

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