SH3YL1

1. SH3YL1 is associated with retinal age gap in humans (β = -0.41 years per effect allele, SE = 0.094, P = 9.8 × 10−6).

   “The lead variant rs17713879 (SH3YL1) replicated after multiple-testing correction (β = -0.41 years per effect allele, standard error = 0.094, P = 9.8 × 10−6).”

   Humansper effect allele

   Replication of the Association between Retinal Aging Clock Susceptibility Genes and Retinal Age Gap in an Asian Population: The Nagahama Study

   Ophthalmology science·Feb 26, 2026

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