AgingResearch.NewsJoin free

Nipped-A

There is 1 paper on Nipped-A in aging research: none in people yet, 1 in animals.

Gene

1 paper studies it2 findings

Taxon

See all 1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Bundesministerium für Forschung, Technologie und Raumfahrt and 1 more
  • Model organisms1

Effects

2

Expression in old intestinal stem cells

upin flies1

1 study

  1. Nipped-A increases expression in old intestinal stem cells in flies (RNA sequencing of young versus old intestinal stem cells).

    “as a regulator of ISC proliferation that is upregulated in old ISCs”

    Model organismsRNA sequencing of young versus old intestinal stem cellsintestinal stem cells

    Nipped-A regulates intestinal stem cell proliferation in Drosophila

    Development (Cambridge, England)

More on Expression in old intestinal stem cells

Intestinal stem cell proliferation

is required forin flies1

1 study

  1. Nipped-A is required for intestinal stem cell proliferation in flies during aging and in response to tissue-damaging or tumorigenic stimuli; shown by knockdown.

    “We show that Nipped-A is required for maintaining the proliferative capacity of ISCs during aging and in response to tissue-damaging or tumorigenic stimuli.”

    Model organismsduring aging and in response to tissue-damaging or tumorigenic stimuli; shown by knockdownintestinal stem cells

    Nipped-A regulates intestinal stem cell proliferation in Drosophila

    Development (Cambridge, England)

Latest

Related