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mtDNA heteroplasmy and mtRNA modifications

Biomarker

3 findings

Effects

1

mtDNA gene expression

mediatesin humans1

1 study

  1. mtDNA heteroplasmy and mtRNA modifications mediate mtDNA gene expression in humans (9 instances).

    “we find 9 instances where these variations mediate donor age effects on mtDNA gene expression.”

    Humansmediation of donor age effects

    Tissue-specific apparent mtDNA heteroplasmy and its relationship with ageing and mtDNA gene expression

    bioRxiv (Cold Spring Harbor Laboratory)16 Dec 2024Preprint

More on mtDNA gene expression

Associations

2

mtDNA gene expression

mixedin humans1

1 study

  1. mtDNA heteroplasmy and mtRNA modifications are associated with mtDNA gene expression in humans (784 associations).

    “We identify 109 associations between them and donor age, and 784 associations with tissue-specific mtDNA gene expression.”

    Humans49 tissues

    Tissue-specific apparent mtDNA heteroplasmy and its relationship with ageing and mtDNA gene expression

    bioRxiv (Cold Spring Harbor Laboratory)16 Dec 2024Preprint

More on mtDNA gene expression

Donor age

mixedin humans1

1 study

  1. mtDNA heteroplasmy and mtRNA modifications are associated with donor age in humans (109 associations).

    “We identify 109 associations between them and donor age, and 784 associations with tissue-specific mtDNA gene expression.”

    Humans49 tissues

    Tissue-specific apparent mtDNA heteroplasmy and its relationship with ageing and mtDNA gene expression

    bioRxiv (Cold Spring Harbor Laboratory)16 Dec 2024Preprint

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