Insulin-induced decline in skeletal muscle acetyl-CoA carboxylase phosphorylation

Older age is associated with insulin-induced decline in skeletal muscle acetyl-CoA carboxylase phosphorylation in humans (-24% versus -56% in aged versus young individuals).

“the insulin-induced decline in skeletal muscle ACC phosphorylation was blunted in the aged compared to young individuals (-24% vs. -56%, P < 0.05).”

Human trialduring insulin stimulationskeletal muscle60 minutesn = 15

Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction

Biochemical and biophysical research communications·Sep 28, 2016