Annual variant allele frequency increase

Biomarker1 paper1 finding

  • Humans1

Associations

1

Malignant progression

upin humans1

1 study
  1. Annual variant allele frequency increase predicts malignant progression in humans.

    HumansChronic idiopathic neutropenia; annual VAF increase ≥7.5%Median follow-up of 32 monthsn = 104

    Blood-cell mutation patterns linked to cancer progression · HemaSphere · 6 Oct 2026

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HemaSphereHumans

Blood-cell mutation patterns linked to cancer progression

A yearly rise of at least 7.5% in mutated gene copies’ share best predicted cancer progression among patients with unexplained low counts of certain…A yearly rise of at least 7.5% in mutated gene copies’ share best predicted cancer progression among patients with unexplained low counts of certain white blood cells.