No phaseRecruitingAge-related condition
Multimodal Assessment of NMES Effects on Respiratory and Peripheral Muscles in COPD (NMES in COPD)
COMPARATIVE EFFECTS OF TARGETED NEUROMUSCULAR ELECTRICAL STIMULATION (NMES) ON RESPIRATORY AND PERIPHERAL MUSCLES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD): A MULTIMODAL ASSESSEMENT USING DIAPHRAGM ULTRASOUND AND PLASMA BIOMARKERS (IL-6 AND IGF-1)
- Sponsor
- Universitas Padjadjaran (Academic or other)
- Enrollment
- 45 planned
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD); Respiratory Muscle Dysfunction; Muscle Weakness
- Interventions
- Neuromuscular Electric Stimulation; Exercise
- Ages
- adults, older adults
- Registry
- NCT07910006
Full record on ClinicalTrials.gov
From the registry
The goal of this clinical trial is to learn if targeted neuromuscular electrical stimulation (NMES) can treat respiratory and peripheral muscle weakness in patients with chronic obstructive pulmonary disease (COPD). The main questions it aims to answer are: * Does targeted NMES improve diaphragm thickening fraction and excursion as measured by diaphragm ultrasound? * What are the comparative effects of targeted NMES on plasma biomarkers, specifically Interleukin-6 (IL-6) and Insulin-like Growth Factor-1 (IGF-1)? Researchers will compare three groups: the first intervention group receiving intercostal NMES combined with Pursed-Lip Breathing (PLB), the second intervention group receiving quadriceps NMES combined with PLB, and a control group receiving sham upper trapezius NMES combined with PLB, to see if targeted NMES provides superior improvements in respiratory and peripheral muscle function. Participants will: * Undergo baseline screening, including a diaphragm ultrasound and a blood draw for plasma biomarkers (IL-6 and IGF-1) * Be randomly assigned to one of the three groups…
Primary outcomes
- Diaphragm Excursion (DE)
- Diaphragm Thickening Fraction (TF)
History
Study completion expected
Primary completion expected
Registered
Started