No phaseRecruitingAge-related condition
Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease
Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gastrointestinal Function in Parkinson's Disease - an Experimental Medicine Study
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust (Academic or other)
- Enrollment
- 72 planned
- Conditions
- REM Sleep Behavior Disorder; Parkinson s Disease
- Interventions
- Ginger
- Ages
- adults, older adults
- Registry
- NCT07882108
Full record on ClinicalTrials.gov
From the registry
This study will test whether taking ginger supplements can increase ghrelin, a hunger hormone that is decreased in the blood of people with Parkinson's disease (PD) and REM Sleep Behaviour disorder (RBD). Three groups of participants are taking part: 1. People with Parkinson's disease (PD); 2. People with REM Sleep Behaviour Disorder (RBD); 3. Healthy people of similar age and sex. The investigators aim to include 24 participants per group. Each participant will take ginger capsules for 12 weeks at one of two dose levels (0.24g or 0.48g of ginger root extract supplement) allocated at random. The main goal is to find out whether ginger causes a dose-related increase in blood ghrelin levels. Secondary goals are to explore whether ginger: 1. reduces levels of inflammation in the blood 2. improves gut symptoms including constipation 3. is well tolerabled in people with Parkinons's If the study shows that ginger increases ghrelin levels, it will provide important early evidence to support a future larger clinical trial to determine whether ginger supplements could help slow or…
Primary outcomes
- Change in fasting blood acylated and unacylated ghrelin levels in PD, RBD and controls over 12 weeks of ginger supplementation.
History
Study completion expected
Primary completion expected
Last registry update
Registered
Started