Phase 2Recruiting
Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension (KARDINAL-ASH)
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Two-Part Study to Evaluate the Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension
- Sponsor
- Kardigan, Inc. (Industry)
- Enrollment
- 140 planned
- Conditions
- Hypertension; Acute Severe Hypertension; Hypertensive Emergency; Hypertensive Urgency
- Interventions
- Tonlamarsen; Placebo
- Ages
- adults, older adults
- Registry
- NCT07511361
Full record on ClinicalTrials.gov
From the registry
The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrently experienced an episode of acute severe hypertension.
Primary outcomes
- Part A: To assess variability in clinical and biomarker measures to inform Part B sample-size estimation and study-design assumptions
- Part B: To assess the pharmacodynamic (PD) effect of tonlamarsen on plasma AGT levels
History
Study completion expected
Primary completion expected
Last registry update
Started
Registered