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Carbon Dioxide Administration and Brain Waste Clearance (COPETBI)

Mechanisms Underlying Carbon Dioxide Induced Protein Efflux in Health and Traumatic Brain Injury

Sponsor
Andrew Mayer (Academic or other)
Enrollment
200 planned
Conditions
Traumatic Brain Injury; Aging Disorder; Magnetic Resonance Imaging (MRI)
Interventions
Hypercapnia task performed during fMRI
Ages
adults, older adults
Registry
NCT07357090

Full record on ClinicalTrials.gov

From the registry

The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood. The investigators believe that this would be a proxy for the brain clearing waste products more effectively. The current study will use a counter-balanced design, in which individuals with and without a history of traumatic brain injury (TBI) will receive different levels of CO2 (targeted changes of approximately 5 or 10 mmHG in end-tidal CO2) approximately one week apart. The counter-balanced design means that each participant receives a single dose of CO2 at each visit, and different doses of CO2 at each visit. The order in which participants receive the dose is randomized, and the participant will not be informed of the dose.

Primary outcomes

  • Cerebrovascular Reactivity (CVR), vascular-elicited bulk cerebral spinal fluid (VE-bCSF)
  • Protein Efflux (Surrogate Measure of Brain Waste Clearance)

History

  1. Study completion expected

  2. Primary completion expected

  3. Expected to start

  4. Last registry update

  5. Registered