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CompletedAge-related condition

Impact of PSA-based Screening on Mortality Among Men Aged 75-79: Target Trial Emulation

Sponsor
Karolinska Institutet (Academic or other)
Enrollment
257,275 enrolled
Conditions
Prostate Cancer; Prostate Cancer Screening; Prostate Cancer Screening Decision; Prostate Specific Antigen Screening
Interventions
Prostate specific antigen (PSA)
Ages
older adults
Registry
NCT07206693

Full record on ClinicalTrials.gov

From the registry

Opportunistic prostate-specific antigen (PSA) testing is widespread among men aged 75-79. Current American and European guidelines recommend PSA-based screening through shared decision-making if men are expected to live at least 10 more years-a threshold previously tied to ages 70-74. With rising life expectancy, Swedish men aged 75-79 now exceed this benchmark, averaging over 10 years. Since no randomized controlled trials have examined screening in this age group, this study will use data from the Stockholm Prostate Cancer Diagnostics Register (2007-2023) to emulate a target trial. Men without prior prostate cancer will be assigned to screened or unscreened groups based on PSA test records and followed until death or December 2023. Analyses will use survival models, cumulative incidence functions, and sensitivity checks (e.g., varying follow-up duration, calendar year vs. age enrollment, and comparisons with men aged 65-69). The goal is to determine whether PSA screening at ages 75-79 improves overall and prostate cancer-specific survival, and whether guidelines should expand to…

Primary outcomes

  • All-cause mortality
  • Prostate-cancer specific mortality

History

  1. Registered

  2. Primary completion

  3. Started

Papers citing this trial