Phase 2Recruiting
Myofascial Dysfunction in Post Stroke Shoulder Pain
Quantifying and Treating Myofascial Dysfunction in Post Stroke Shoulder Pain
- Sponsor
- Johns Hopkins University (Academic or other)
- Enrollment
- 68 planned
- Conditions
- Stroke
- Interventions
- hyaluronidase plus saline; saline
- Ages
- adults, older adults
- Registry
- NCT06718413
Full record on ClinicalTrials.gov
From the registry
Shoulder pain is extremely common after stroke and occurs in 30-70% of patients. The pain may begin as early as one week after stroke, although peak onset and severity occurs around four months, and persists into the chronic stage. Chronic post stroke shoulder pain (PSSP) interferes with motor recovery, decreases quality of life, and contributes to depression. PSSP is thought to be caused mainly by damage to the myofascial tissues around the shoulder joint. Interestingly, an MRI study in patients with PSSP showed that the degree of structural damage to the muscles did not correlate with the degree of pain. Thus, the pathophysiology of myofascial dysfunction and pain in PSSP has not been elucidated leading to missed opportunities for early diagnosis and variable success with pain management. The accumulation of hyaluronic acid (HA) in muscle and its fascia can cause myofascial dysfunction. HA is a glycosaminoglycan (GAG) consisting of long-chain polymers of disaccharide units of glucuronic acid and N-acetylglucosamine and is a chief constituent of the extracellular matrix of muscle.…
Primary outcomes
- T1ρ relaxation times (ms) in the treatment group
History
Study completion expected
Primary completion expected
Last registry update
Started
Registered