No phaseRecruitingAge-related condition
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Precision Medicine in Alzheimer's Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-Fitness Responses (The FIT-AD SMART Trial)
- Sponsor
- Arizona State University (Academic or other)
- Enrollment
- 216 planned
- Conditions
- Mild Cognitive Impairment; Alzheimer Disease; Cognitive Impairment; Cognitive Decline; Memory Loss; Memory Impairment
- Interventions
- Moderate Intensity Continuous Training (MICT); Chair-based Stretch; High-Intensity Interval Training (HIIT); Combined Aerobic Resistance Exercise (CARE)
- Ages
- older adults
- Registry
- NCT05877196
Full record on ClinicalTrials.gov
From the registry
The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes; * identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and * examines the mechanisms of aerobic exercise's action on memory in older adults with early AD. Participants will receive 6 months of supervised exercise, undergo cognitive data collection and exercise testing 5 times over a year span, have an MRI brain scan 3 times over a one-year span, and have monthly follow-up discussions on health and wellness.
Primary outcomes
- Peak oxygen consumption
- White Matter Hyperintensity volume
History
Study completion expected
Primary completion expected
Last registry update
Started
Registered