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Resistance vs. Aerobic Training on Breast Cancer Patients Undergoing Neoadjuvant Treatment (NEO-Program)

Effects of Resistance vs. Aerobic Training on Ki-67 and Other Health-Related Biomarkers: The NEO-Program, a Randomized Controlled Trial on Breast Cancer Patients Undergoing Neoadjuvant Treatment

Sponsor
Fundacao Champalimaud (Academic or other)
Enrollment
132 enrolled
Conditions
Breast Cancer
Interventions
Aerobic Training Group; Resistance Training Group; Control group
Ages
adults, older adults
Registry
NCT05297773

Full record on ClinicalTrials.gov

From the registry

A recent consensus study suggested that understanding the impact of exercise on the tumor microenvironment and therapy effectiveness is paramount and should be considered as a research priority. Therefore, the research team intends to address some of the scientific challenges proposed, which represent clear gaps in the current knowledge. The investigators propose a randomized controlled trial conducted during all neoadjuvant treatment duration that aims to evaluate and compare the effects of two different exercise protocols (aerobic and resistance training) against a relaxation control group on Ki-67% changes as the main outcome in breast cancer patients. Secondary outcomes will be body composition; resting metabolic rate; physical fitness; quality of life, fatigue, depression/anxiety; accelerometry data (physical activity levels, sedentary time); sleep quality; tumor biology (size, hypoxia, and immune profile); glycemic, lipid, and inflammatory profile. This project will help not only researchers with the design of future exercise intervention protocols but will also help…

Primary outcomes

  • Changes from baseline Ki67% at the end of the intervention

History

  1. Last registry update

  2. Primary completion

  3. Started

  4. Registered

Papers citing this trial