Phase 4Status unknownHealthspan endpoint
Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery (ALPHA2PREVENT)
Alpha 2 Adrenergic Receptor Agonists for the Prevention of Delirium and Cognitive Decline After Open Heart Surgery (ALPHA2PREVENT): Randomised Controlled Trial.
- Sponsor
- Oslo University Hospital (Academic or other)
- Enrollment
- 900 planned
- Conditions
- Delirium; Cognitive Decline; Frailty
- Interventions
- Dexmedetomidine; Clonidine; Natriumchlorid
- Ages
- older adults
- Registry
- NCT05029050, EUCTR2021-001645-12
Full record on ClinicalTrials.gov
From the registry
A parallel-group treatment, five-centre, participant and investigator masked, three-arm study to assess the safety and effectiveness of dexmedetomidine or clonidine infusion compared to placebo for the prevention of delirium and cognitive decline in male and female participants aged 70+ scheduled for open heart surgery.
Primary outcomes
- Postoperative delirium
History
Study completion
Primary completion
Last registry update
Started
Registered