Men at High Genetic Risk for Prostate Cancer

Background: Research studies have shown that genetic changes and family history may increase a man s risk for prostate cancer. Researchers want to follow the prostate health of men who have specific genetic changes associated with prostate cancer to help them learn more about which men are at higher risk for prostate cancer. Objectives: To study men with specific genetic changes and determine who is at higher risk for getting prostate cancer. To study if certain genetic changes and family history can be used to help prevent or treat prostate cancer. Eligibility: Males between ages 30-75 who have one or more specific genetic changes but without prostate cancer. Design: * This study does not perform genetic testing. All participants must have documented genetic changes and able to provide a copy of the report. * Before enrollment, participants will provide a copy of documented genetic changes and go through a telephone interview to determine eligibility for the study. * On enrollment, participants will have medical and family history review, medication review, physical exam,…

• Natural history of high genetic risk for prostate cancer

1. Study completion expected

   Jan 1, 2039

2. Primary completion expected

   Jan 1, 2029

3. Last registry update

   Oct 16, 2026

4. Started

   Mar 27, 2019

5. Registered

   Jan 16, 2019