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Epidural Anesthesia-analgesia and Long-term Outcome
Impact of Epidural Anesthesia-analgesia on Long-term Outcome in Elderly Patients After Surgery: 5-year Follow-up of a Multicenter Randomized Controlled Trial
- Sponsor
- Peking University First Hospital (Academic or other)
- Enrollment
- 1,802 enrolled
- Conditions
- Elderly; Malignant Tumor; Surgical Resection; Epidural Anesthesia; Long-term Outcome
- Interventions
- Combined epidural-general anesthesia; General anesthesia
- Ages
- adults, older adults
- Registry
- NCT03012945
Full record on ClinicalTrials.gov
From the registry
Surgical resection is one of the most important treatments for resectable cancer; on the other hand, cancer recurrence and/or metastasis are the major reasons of treatment failure. The development of recurrence/metastasis after cancer surgery mostly depends on the balance between the immunity of human body and the capability of implantation, proliferation and neovascularization of the residual cancer. Preclinical and retrospective clinical studies suggest that anaesthetic management may affect the long-term outcomes after cancer surgery. The investigators hypothesize that use of epidural anesthesia-analgesia may improve long-term survival in elderly patients after major surgery for cancer.
Primary outcomes
- Overall survival after surgery.
History
Last registry update
Primary completion
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