No phaseCompletedAge-related condition
Intervention With Selenium and Q10 on Cardiovascular Mortality and Cardiac Function in the Elderly Population in Sweden (KiSel-10)
Kisel-10- a Prospective Randomized Double-blind Placebo Controlled Study of the Results of Intervention With Selenium and Coenzyme Q10 Combined, Regarding Effect With Emphasis on Cardiovascular Mortality and Morbidity.
- Sponsor
- University Hospital, Linkoeping (Academic or other)
- Enrollment
- 443 enrolled
- Conditions
- Cardiovascular Mortality; Cardiac Function
- Interventions
- Selenium and ubiquinon (Q10) combined
- Ages
- older adults
- Registry
- NCT01443780
Full record on ClinicalTrials.gov
From the registry
The dietary supplements selenium and Q10 has been evaluated in a double blind placebo-controlled study in an elderly Swedish population. The hypothesis is that as a majority of Northern Europeans suffers insufficient levels of selenium that is used by the cell in the building of at least 25 different enzyme systems in the body, and that the cell need presence of Q10 in order to produce the selenium containing enzymes, we wanted to evaluate the effect of a combined intervention of the two supplements in an elderly population in Sweden. All participants were controlled every 6 months, and the intervention was 48 months in each participant. Besides blood samples, echocardiography and cardiac natriuretic peptides were analyzed at start, every 6 months and at end of the study.
Primary outcomes
- Change in cardiovascular and all-cause mortality as effect of intervention
History
Last registry update
Registered
Primary completion
Started
Papers citing this trial
- Supplementation with selenium and coenzyme Q₁₀ in an elderly Swedish population low in selenium - positive effects on thyroid hormones, cardiovascular mortality, and quality of life
BMC medicine
- Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden
European journal of nutrition
- Decreased Concentration of Fibroblast Growth Factor 23 (FGF-23) as a Result of Supplementation with Selenium and Coenzyme Q₁₀ in an Elderly Swedish Population: A Sub-Analysis
Cells
- Supplemental selenium and coenzyme Q10 reduce glycation along with cardiovascular mortality in an elderly population with low selenium status - A four-year, prospective, randomised, double-blind placebo-controlled trial
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
- Significant Changes in Metabolic Profiles after Intervention with Selenium and Coenzyme Q10 in an Elderly Population
Biomolecules
- Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly
PloS one
- Supplementation with Selenium and Coenzyme Q10 Reduces Cardiovascular Mortality in Elderly with Low Selenium Status. A Secondary Analysis of a Randomised Clinical Trial
PloS one
- Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
International journal of cardiology