Phase 4TerminatedAge-related condition
TOM: Testosterone in Older Men With Sarcopenia
Testosterone Replacement for Older Men With Sarcopenia
- Sponsor
- Boston Medical Center (Academic or other)
- Enrollment
- 209 enrolled
- Conditions
- Sarcopenia; Hypogonadism; Muscular Diseases
- Interventions
- Topical testosterone gel 1% (active formulation); Topical gel (placebo formulation)
- Ages
- older adults
- Registry
- NCT00240981
Full record on ClinicalTrials.gov
From the registry
The purpose of this study is to determine whether testosterone replacement in older men with low testosterone levels will increase muscle strength, improve physical performance and overall sense of well being, and reduce fatigue.
Primary outcomes
- Changes in Physical Performance Measured by an Exercise Testing Regimen
History
Results first posted
Last registry update
Primary completion
Registered
Started
Papers citing this trial
- Testosterone replacement in men with sexual dysfunction
The Cochrane database of systematic reviews
- Long-Term Testosterone Supplementation in Older Men Attenuates Age-Related Decline in Aerobic Capacity
The Journal of clinical endocrinology and metabolism
- Contributors to the substantial variation in on-treatment testosterone levels in men receiving transdermal testosterone gels in randomized trials
Andrology
- Testosterone does not affect agrin cleavage in mobility-limited older men despite improvement in physical function
Andrology
- Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation
The journals of gerontology. Series A, Biological sciences and medical sciences
- Adverse events associated with testosterone administration
The New England journal of medicine
- Effects of testosterone therapy on muscle performance and physical function in older men with mobility limitations (The TOM Trial): design and methods
Contemporary clinical trials