Papers by Jean-Charles Lambert · AgingResearch.News

Nature Genetics15 Sep
APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease
Study in peopleMechanisms
Paper
medRxiv14 Sep
Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease
Preprint: genetic association study of 355,180 peopleCerebral small vessel disease
Paper
American Journal of Human Genetics26 Aug
Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk
Study in peopleMechanisms
Paper
Nature Genetics15 Aug
PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures
Experiments in cellsMechanisms
Paper

Alzheimer's & Dementia8 Aug
APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome
Study in peoplePopulations
Paper
Annals of Neurology4 Aug
Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk
Study in peopleMechanisms
Paper
AAIC 2025 Abstract24 Dec
GIGAVCID: A Genome‐Wide Meta‐Analysis of 1.1 Million Individuals Identifies Novel Genetic Loci for Vascular Cognitive Impairment
Study in peopleMechanisms
Paper