TherapeuticsMD

CompanyUnited StatesFounded 1907

TherapeuticsMD develops 3 assets, the furthest approved (estradiol in atrophic vaginitis). Mostly small molecule acting on ESR2, inflammation and ESR1; based in the United States, founded in 1907.

3
Assets
Furthest: Approved; 4
Trials: 0
Signals

Pipeline

estradiol
Estrogen receptor agonist for hormone replacement
Approved, Small molecule, ESR2, Inflammation, atrophic vaginitis, hypogonadism
oestradiol
Estrogen receptor agonist for hormone replacement
Approved, Small molecule, ESR2, Inflammation, atrophic vaginitis, hypogonadism
progesterone
Activates progesterone receptors to support pregnancy and maintain uterine quiescence.
Approved, Small molecule, PGR, Amenorrhea, endometrial hyperplasia

Full company profiles: pipeline, trials, funding and people.

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In the full profile

Evidence behind the mechanisms6
Trials5
Similar companies6

Updated 10 Oct 2026 · 147 sources