Cumulative layoffs
Intervention1 paper2 findings
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
Funder: National Institute on Aging
- Humans1
Outcomes
2Attention, orientation, or language domains
no changein humans1
1 study
Attention, orientation, or language domains
no changein humans1
Cumulative layoffs have no effect on attention, orientation, or language domains in humans.
Humans41 yearsn = 6,421
Cumulative layoffs in adulthood and cognitive function in mid-to-later life among US working-age adults, 1979-2020 · American journal of epidemiology · 8 Sep 2026
Episodic memory
downin humans1
1 study
Episodic memory
downin humans1
Cumulative layoffs impair episodic memory in humans (β = -0.086, 95% CI: -0.171 to -0.001).
Humans41 yearsn = 6,421
Cumulative layoffs in adulthood and cognitive function in mid-to-later life among US working-age adults, 1979-2020 · American journal of epidemiology · 8 Sep 2026