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Five-protein pre-diagnostic ALS biomarker signature

There is 1 paper on five-protein pre-diagnostic ALS biomarker signature in aging research: 1 observational study in people.

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See all 1 papers on five-protein pre-diagnostic ALS biomarker signature

“Five proteins (SECTM1, CA3, THAP4, KLHL41, SLC26A7) were identified as significant pre-diagnostic ALS biomarkers (FDR=0.05), detectable approximately two decades before diagnosis.”
Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvementmedRxiv : the preprint server for health sciences2025doi:10.1101/2025.08.20.25334061
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Future amyotrophic lateral sclerosis diagnosis

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  1. Five-protein pre-diagnostic ALS biomarker signature predicts future amyotrophic lateral sclerosis diagnosis in humans (Initially healthy participants) (FDR=0.05).

    “Five proteins (SECTM1, CA3, THAP4, KLHL41, SLC26A7) were identified as significant pre-diagnostic ALS biomarkers (FDR=0.05), detectable approximately two decades before diagnosis.”

    HumansInitially healthy participantsplasmaApproximately two decades before diagnosisn = 4,567

    Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

    medRxiv : the preprint server for health sciencesPreprint

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