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Phase 3Recruiting

Parasitic Ulcer Treatment Trial (PUTT)

Sponsor
Jeremy Keenan, MD, MPH (Academic or other)
Enrollment
232 planned
Conditions
Acanthamoeba Keratitis
Interventions
Polyhexamethylene biguanide (PHMB); Topical corticosteroid; Topical placebo
Ages
children, adults, older adults
Registry
NCT06213649

Full record on ClinicalTrials.gov

From the registry

The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regimen for acanthamoeba keratitis (AK) will improve vision. Patients presenting to all enrollment centers with evidence of acanthamoeba keratitis will be eligible for the trial if there is evidence of ocular inflammation after 4 weeks of anti-amoebic therapy. Those who agree to participate will be randomized to one of two treatment groups: * Group 1: Topical corticosteroid * Group 2: Topical placebo

Primary outcomes

  • Vision

History

  1. Primary completion expected

  2. Last registry update

  3. Started

  4. Registered